Doxycycline
Doxycycline is a broad-spectrum antibiotic of tetracycline group.
It inhibits the protein synthesis in the microbial cell and has a bacteriostatic action. The drug is efficient as for most gram-positive and gram-negative bacteria, including Mycoplasma, Clamydia, Rickettsia, Yersinia, Brucella, Vibrio, Bacteroides, Clostridium, Fusiformis, and animalcules (malaria parasite, amoeba, etc.). Doxycycline penetrates inside the cell, inhibiting the reproduction of intracellular causative agents.
Doxycycline is rapidly absorbed, its bioavailability is 95%. The effective antibiotic concentration is lasting only for 18-24 hours. The drug penetrates into the most body tissues and fluids, into the bile, exudates of maxillary and frontal sinuses, pleural, synovial, ascitic fluid. Antibiotic accumulates in bones, teeth, liver, spleen, prostate gland and excreted with gall (90%) and urine.
Side effects: gastroenteric upsets, mucous membrane irritation, allergic reactions, photosensitization, sustainable changing the color of tooth enamel, hemolytic anemia, thrombocytopenia, neutropenia, during long-term ingestion - dysbacteriosis, yeast-like fungi superinfection.
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